2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-E70666
    CDK17/p35NCK Recombinant Human Active Protein Kinase
    CDK17 is highly expressed in terminally differentiated neurons, particularly those found in hippocampal regions and olfactory bulbs. CDK17/p35NCK Recombinant Human Active Protein Kinase is an ortholog of CDK17.
    CDK17/p35NCK Recombinant Human Active Protein Kinase
  • HY-E70667
    CDK18/CycY Recombinant Human Active Protein Kinase
    CDK18 is a neuronal kinase that phosphorylates TAU protein when overexpressed in human brain. CDK18 shares a conserved PCTAIRE amino acid sequence in the helical α-C region of the kinase N-lobe. CDK18/CycY Recombinant Human Active Protein Kinase is an ortholog of CDK18.
    CDK18/CycY Recombinant Human Active Protein Kinase
  • HY-E70684
    CDK5/p25NCK Recombinant Human Active Protein Kinase
    CDK5 can be mapped to chromosome 7q36 and its expression is upregulated by the transcription factors Fos and CREB through the MEK/ERK pathway and by δFosB. CDK5 plays a vital role in the central nervous system but has functions in other cell types. CDK5 has recently been implicated in diseases, including the development and progression of cancer and neurodegenerative diseases. CDK5/p25NCK Recombinant Human Active Protein Kinase is an ortholog of CDK5.
    CDK5/p25NCK Recombinant Human Active Protein Kinase
  • HY-E70685
    CDK5/p35NCK Recombinant Human Active Protein Kinase
    CDK5 can be mapped to chromosome 7q36 and its expression is upregulated by the transcription factors Fos and CREB through the MEK/ERK pathway and by δFosB. CDK5 plays a vital role in the central nervous system but has functions in other cell types. CDK5 has recently been implicated in diseases, including the development and progression of cancer and neurodegenerative diseases. CDK5/p35NCK Recombinant Human Active Protein Kinase is an ortholog of CDK5.
    CDK5/p35NCK Recombinant Human Active Protein Kinase
  • HY-E70807
    Biotin-WNK3 Recombinant Human Active Protein Kinase
    WNK3 is a WNK kinase that associates with and activate SPAK/OSR1 by phosphorylation of its T-loop at Thr233 and Thr185. Biotin-WNK3 Recombinant Human Active Protein Kinase is obtained by expressing WNK3 proteins and is biotinylated.
    Biotin-WNK3 Recombinant Human Active Protein Kinase
  • HY-E70813
    CAMKK2 Recombinant Human Active Protein Kinase
    CaMKK2 is a serine/threonine protein kinase and the central component of a Ca2+-calmodulin activated signalling pathway. CaMKK2 is highly enriched in brain neurons and regulates energy metabolism and neuronal processes. CAMKK2 Recombinant Human Active Protein Kinase is obtained by expressing CAMKK2 proteins.
    CAMKK2 Recombinant Human Active Protein Kinase
  • HY-E70869
    TRKA(NTRK1) Recombinant Human Active Protein Kinase
    TRKA (also named NTRK1) is a potential new member of the tyrosine kinase gene family. TRKA is a receptor tyrosine kinase that is phosphorylated in response to NGF. A single transmembrane domain divides TRKA into an extracellular domain, important for NGF binding, and an intracellular tyrosine kinase domain, important for signal transduction. TRKA(NTRK1) Recombinant Human Active Protein Kinase is a recombinant TRKA(NTRK1) protein that can be used to study TRKA(NTRK1)-related functions.
    TRKA(NTRK1) Recombinant Human Active Protein Kinase
  • HY-E70870
    TRKB(NTRK2) Recombinant Human Active Protein Kinase
    TRKB(NTRK2) is a member of tyrosine kinase gene family. TRKB is the primary receptor for brain-derived nerve growth factor (BDNF) and neurotrophin 4/5 (NT4/5). TRKB(NTRK2) Recombinant Human Active Protein Kinase is a recombinant TRKB(NTRK2) protein that can be used to study TRKB(NTRK2)-related functions.
    TRKB(NTRK2) Recombinant Human Active Protein Kinase
  • HY-E70871
    TTBK2 Recombinant Human Active Protein Kinase
    TTBK2 is a tau tubulin kinase. Mutations in TTBK2 cause spinocerebellar ataxia type 11, a disorder exhibiting both loss of Purkinje cells and widespread deposition of tau. TTBK2 Recombinant Human Active Protein Kinase is a recombinant TTBK2 protein that can be used to study TTBK2-related functions.
    TTBK2 Recombinant Human Active Protein Kinase
  • HY-E70910
    Dopamine β-monooxygenase, Human
    Dopamine β-monooxygenase, Human (EC 1.14.17.1) is a copper-containing monooxygenase that converts dopamine into norepinephrine in noradrenergic neurons, adrenergic neurons, and adrenacentrocytes.
    Dopamine β-monooxygenase, Human
  • HY-E70950
    Calmodulin-dependent Protein Kinase II, Rat
    Calmodulin-dependent protein kinase II, Rat, is a serine-threonine protein kinase involved in neurotransmitter release, stimulation-induced gene expression control, and microtubule-associated protein phosphorylation.
    Calmodulin-dependent Protein Kinase II, Rat
  • HY-E70970
    Catechol-O-methyl Transferase, Porcine
    Catechol-O-methyl Transferase, Porcine (EC 2.1.1.6) is one of several enzymes that degrade catecholamines such as dopamine, epinephrine, and norepinephrine.
    Catechol-O-methyl Transferase, Porcine
  • HY-ER013I
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 497-19-8 98%
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500 is a biochemical assay reagent suitable for buffer configuration.
    Sodium carbonate anhydrous, meets analytical specification of Ph. Eur., BP, NF, FCC, E500
  • HY-G0001S
    Lurasidone Metabolite 14283-d8 2070009-43-5 98%
    Lurasidone Metabolite 14283-d8 is the deuterium labeled Lurasidone Metabolite 14283, which is a metabolite of Lurasidone.
    Lurasidone Metabolite 14283-d8
  • HY-G0002S
    Lurasidone metabolite 14326-d8 2070009-33-3 98%
    Lurasidone metabolite 14326-d8 is the deuterium labeled Lurasidone Metabolite 14326, which is a metabolite of Lurasidone.
    Lurasidone metabolite 14326-d8
  • HY-G0003A
    Milsaperidone 501373-88-2 98%
    Milsaperidone ((S)-Hydroxy Iloperidone) is an active metabolite of the antipsychotic agent Iloperidone (HY-17410). Milsaperidone is a dopamine D2 and 5-HT2A receptor antagonist. Milsaperidone rapidly converts to Iloperidone when taken orally. Milsaperidone can be used in the research of mental illnesses such as depression.
    Milsaperidone
  • HY-G0003R
    Iloperidone metabolite Hydroxy Iloperidone (Standard) 133454-55-4
    Iloperidone metabolite Hydroxy Iloperidone (Standard) is the analytical standard of Iloperidone metabolite Hydroxy Iloperidone (HY-G0003). This product is intended for research and analytical applications. Iloperidone metabolite Hydroxy Iloperidone (P88; Hydroxy Iloperidone) is an active reduced metabolite of Iloperidone (HY-17410). Iloperidone metabolite Hydroxy Iloperidone can be used for the research of schizophrenia.
    Iloperidone metabolite Hydroxy Iloperidone (Standard)
  • HY-G0014S
    Quetiapine Sulfoxide-d8 1330238-38-4 98%
    Quetiapine Sulfoxide-d8 is the deuterium labeled Quetiapine sulfoxide. Quetiapine sulfoxide (Quetiapine S-oxide) is a main metabolite of Quetiapinem. Quetiapine is a second-generation antipsychotic. Quetiapine is a 5-HT receptors agonist and a dopamine receptor antagonist.
    Quetiapine Sulfoxide-d8
  • HY-G0017A
    N-Desmethyl imatinib mesylate 404844-03-7 98%
    N-Desmethyl imatinib mesylate (Norimatinib mesylate) is an active metabolite of Imatinib (HY-15463), a selective c‑Abl inhibitor, and a substrate of P‑glycoprotein. N-Desmethyl imatinib mesylate binds to the c-Abl catalytic domain to prevent substrate phosphorylation, inhibits c-Abl-mediated α-synuclein activation and downstream inflammatory signaling pathways. N-Desmethyl imatinib mesylate induces apoptosis in K562 human leukemia cells. N-Desmethyl imatinib mesylate exhibits significantly elevated plasma levels in gastrointestinal stromal tumor (GIST) settings following mild SARS CoV 2 infection. N-Desmethyl imatinib mesylate can be used for the research of Parkinson’s disease, gastrointestinal stromal tumor, and chronic myeloid leukemia.
    N-Desmethyl imatinib mesylate
  • HY-I0096S
    Indole-2-carboxylic acid-13C 1216839-31-4 98%
    Indole-2-carboxylic acid-13C is the 13C-labeled Indole-2-carboxylic acid. Indole-2-carboxylic acid is a strong inhibitor of lipid peroxidation. Indole-2-carboxylic acid (I2CA) specifically and competitively inhibits the potentiation by glycine of NMDA-gated current.
    Indole-2-carboxylic acid-13C
Cat. No. Product Name / Synonyms Application Reactivity